Hepatitis B is a highly infectious disease caused Hepatitis B Virus. It damages the liver parenchyma. Complications of this disease are Liver Cirrhosis and Portal Hypertension. It may also lead to Hepato-cellular Carcinoma It is a major health hazard around the globe because of its highly infectious nature. No alarming sign and symptoms in early stage of infection are exhibited but lethal damage to the liver takes place in advance stage. Over 750,000 people die of hepatitis B each year. Transmission of HBV takes place through blood or other body fluids. Possible routes of transmission include sexual contact, transfusions of blood and its components, re-use of contaminated needles, syringes and surgical instruments and mother to child during childbirth. Initial results of treatment are encouraging as the patients are not only clinically benefitted but have shown reduction in Viral load. Some have even become seronegative.